Department of Chemistry

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Peter Wipf

Distinguished University Professor

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758 CHVRN
Chevron Science Center, 219 Parkman Avenue

Pittsburgh, PA 15260
412-624-8606

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Research Overview

Total Synthesis of Natural Products; Organometallic and Heterocyclic Chemistry; Medicinal Chemistry

Total Synthesis of Natural Products

Total Synthesis encompasses all aspects of organic chemistry: The development of new methodology, mechanistic and physical organic experiments, conformational and configurational analysis by spectroscopic and computational methods, and bioorganic and medicinal chemistry. Total Synthesis is also one of the broadest and most rewarding educational experiences for aspiring synthetic chemists.

Organometallic Chemistry

Organometallic Chemistry will provide most of new revolutionary techniques for C,C and C-heteroatom bond formations and asymmetric catalysis. Our group has had a long tradition in synthetic applications of transition metals.

Heterocyclic Chemistry

More than half of all known organic compounds, and the vast majority of drugs, are heterocyclic. We are interested in the development of new stereoselective methods for the preparation of highly functionalized heterocycles. In particular, we have developed novel protocols for five-membered heterocycle synthesis that have been widely adopted in industry and academe.

Combinatorial Synthesis & Medicinal Chemistry

We apply combinatorial chemistry and solid phase synthesis methods for reagent and catalyst design in organometallic and heterocyclic chemistry, and for the structure-activity analysis of bioactive natural products. Specifically, we are involved in collaborative drug discovery and development. Some of these projects take advantage of the infrastructure of the Combinatorial Chemistry Center (CCC).

 

Computational Prediction of Macroscopic Properties

In another exciting interdisciplinary collaboration, we have joined forces with the Beratan group for the computational assignment of the relative and absolute stereochemistry of organic molecules of organic molecules and the theoretical prediction of chiroptical phenomena.

 

 

 

 

Recent Advisory And Editorial Boards

  • Editorial Advisory Board, Helvetica Chimica Acta (2016-present)

  • ACS National Awards Selection Committee (2015)

  • Guest Editor for Israel Journal of Chemistry Special Issue on “Flow Chemistry”

  • Organic Syntheses, Inc., Board of Directors (2013-present)

  • Guest Editor for Molecules Special Issue on “Diversity Oriented Synthesis” (2011)

  • External Advisory Committee, Purdue University Center for Cancer Research, West Lafayette, IN (2010-present)

  • Associate Editor, ACS Medicinal Chemistry Letters (2009)-present

  • Honorary Editorial Board, International Journal of High Throughput Screening (2009-present)

  • Organic Reactions, Inc., Board of Directors (2007-present)

  • International Advisory Editorial Board, Organic & Biomolecular Chemistry (2007-present)

Awards

  • Visiting Professor, RWTH Aachen, Aachen, Germany (2016)
  • Chair of the Section on Pharmaceutical Sciences of the American Association for the Advancement of Science (2016)
  • Provost's Award for Excellence in Mentoring (2015)
  • Humboldt Research Award of the Alexander von Humboldt Foundation (2014)
  • Harry and Carol Mosher Award of the Santa Clara Valley Section of the ACS (2013)
  • Edward W. Morley Award of the Cleveland Section of the ACS (2013)

  • ACS Pittsburgh Award (2012)

  • Fellow of the American Chemical Society (2010)

  • Ernest Guenther Award in the Chemistry of Natural Products (2009)

  • Associate Editor, ACS Medicinal Chemistry Letters (2009-present)

  • Organic Reactions, Inc. Board of Directors (2007-present)

  • Chancellor's Distinguished Research Award (2008)

  • Faculty of 1000 Biology (2006-present)

  • Novartis Chemistry Lectureship (2005)

  • Fellow of the Royal Society of Chemistry (FRSC, 2004)

  • Visiting Professor (Professeur Associé), École Supérieur de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), Paris, France (September 2004)
  • Long Range Planning Committee, ACS Division of Medicinal Chemistry (2004-2006)
  • ISHC Katritzky Award in Heterocyclic Chemistry (2003)

  • Fellow of the American Association for the Advancement of Science (AAAS, 2002)
  • Chair, Gordon Research Conference on Stereochemistry, Salve Regina University, Newport, Rhode Island (June 9-14, 2002)
  • Visiting Professor (Professeur Associé), Université de Paris-Sud, Orsay, France (November 2001)
  • Member-at-Large, Organic Division Executive Committee of the ACS (2001-2003)
  • Novartis Research Award (2000, 2001)
  • Japan Society for the Promotion of Science Fellow (2000)

  • Akron Section ACS Award (1998)

  • Arthur C. Cope Scholar Award (1998)

  • NIH Medicinal Chemistry Study Section, Member, 1998-2003, Chairman, 2001-2003

  • Chancellorís Distinguished Research Award (1997)

  • Phi Eta Sigma, Honorary Member (1996)

  • Merck Young Investigator Award (1995)

  • Zeneca Award for Excellence in Chemistry (1995)

  • Camille Dreyfus Teacher-Scholar Award (1995)

  • UCI-Allergan Visiting Lecturer, University of California, Irvine, California (May, 1995)
  • NSF Presidential Faculty Fellow (1994-1999)

  • ETH Ruzicka Award (1994)

  • Alfred P. Sloan Research Fellow (1994-1996)

  • American Cyanamid Faculty Award (1994)

  • Eli Lilly Grantee (1993-1995)

  • University of Zürich, Distinguished Dissertation Award (1987)


Publications

“A Five-Component Biginelli-Diels-Alder Cascade Reaction,” Maskrey, T. S.; Frischling, M. C.; Rice, M. R., Wipf, P. Front. Chem. 2018, 6, 376
“Compensatory Increases of Select Proteostasis Networks after Hsp70 Inhibition in Cancer Cells,” Sannino, S.; Guerriero, C. J.; Sabnis, A. J.; Stolz, D. B.; Wallace, C. T.; Wipf, P.; Watkins, S. C.; Bivona Trever, G.; Brodsky, J. L. J. Cell Sci. 2018, 131 (17)
“Genetic Re-Engineering of Polyunsaturated Phospholipid Profile of Saccharomyces Cerevisiae Identifies a Novel Role for Cld1 in Mitigating the Effects of Cardiolipin Peroxidation,”  Lou, W.; Ting, H.-C.; Reynolds, C. A.; Tyurina, Y. Y.; Tyurin, V. A.; Li, Y.; Ji, J.; Yu, W.; Liang, Z.; Stoyanovsky, D. A.; Anthonymuthu, T. S.; Frasso, M. A.; Wipf, P.; Greenberger, J. S.; Bayir, H.; Kagan, V. E.; Greenberg, M. L. Biochim. Biophys. Acta Mol. Cell Biol. L. 2018, 1863 (10), 1354-1368
“Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways,”  Steinman, J.; Epperly, M.; Hou, W.; Willis, J.; Wang, H.; Fisher, R.; Liu, B.; Bahar, I.; McCaw, T.; Kagan, V.; Bayir, H.; Yu, J.; Wipf, P.; Li, S.; Huq, M. S.; Greenberger, J. S.; Liu, B.; Bavar, I.; Kagan, V.; Bayir, H.; Yu, J.; Wipf, P.; Li, S. Rad. Res. 2018, 189, 68-83
“Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039),” Epperly, M. W.; Fisher, R.; Franicola, D.; Greenberger, J. S.; Wipf, P.; Beumer, J.; Li, S.; Brand, R. M.; Falo, L. D.; Erdos, G. In Vivo 2018, 32, (5), 1009-1023
“Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage,” Brand, R. M.; Wipf, P.; Durham, A.; Epperly, M. W.; Greenberger, J. S.; Falo, L. D., Jr. Front. Pharmcol. 2018, 9, 920
“Reevaluation of the Palladium/Carbon-Catalyzed Decarbonylation of Aliphatic Aldehydes,” Ajdacic, V.; Nikolic, A.; Kerner, M.; Wipf, P.; Opsenica, I. M. Synlett 2018, 29, 1781-1785
“A High-Content Screen Reveals New Small-Molecule Enhancers of as/Mapk Signaling as Probes for Zebrafish Heart Development,”  Saydmohammed, M.; Onuoha, E. O.; Tsang, M.; Vollmer, L. L.; Vogt, A.; Maskrey, T. S.; Wipf, P.; Gibson, G.; Watkins, S. C.; Vogt, A. Molecules 2018, 23, (7), 1691
“A Chemical Genetics Approach Identifies PTP4A3 as a Regulator of Colon Cancer Cell Adhesion,”  McQueeney, K. E.; Ahn, J. G.; Pekic, P.; Blanco, I. K.; Struckman, H. L.; Sharlow, E. R.; Lazo, J. S.; Salamoun, J. M.; Wipf, P. FASEP J. 2018
“Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca(-/-) and Fancg(-/-) Mice by Intraoral Administration of GS-Nitroxide (JP4-039),” Willis, J.; Epperly, M. W.; Fisher, R.; Zhang, X.; Shields, D.; Hou, W.; Wang, H.; Steinman, J.; Greenberger, J. S.; Li, S.; Wipf, P.; Parmar, K.; Guinan, E. Radiat. Res. 2018, 189, (6), 560-578
“ATF4 Regulates Cd4+ T Cell Immune Responses through Metabolic Reprogramming,” Yang, X.; Xia, R.; Yue, C.; Zhai, W.; Du, W.; Yang, Q.; Cao, H.; Chen, X.; Obando, D.; Zhu, Y.; Chen, X.; Chen, J.-J.; Piganelli, J.; Wipf, P.; Jiang, Y.; Xiao, G.; Wu, C.; Jiang, J.; Lu, B. Cell Rep. 2018, 23, (6), 1754-1766
“Targeting Ovarian Cancer and Endothelium with an Allosteric PTP4A3 Phosphatase Inhibitor,” McQueeney, K. E.; Salamoun, J. M.; Burnett, J. C.; Barabutis, N.; Lewandowski, S. L.; Llaneza, D. C.; Cornelison, R.; Bai, Y.; Zhang, Z.-Y.; Catravas, J. D.; Landen, C. N.; Wipf, P.; Lazo, J. S.; Sharlow, E. R. Oncotarget 2018, 9, (9), 8223-8240
“XJB-5-131-Mediated Improvement in Physiology and Behaviour of the R6/2 Mouse Model of Huntington's Disease Is Age- and Sex-Dependent,” Polyzos, A. A.; Williams, P.; McMurray, C. T.; Wood, N. I.; Morton, A. J.; Wipf, P. PLoS One 2018, 13, (4)
“Development of an Undergraduate Course in Chemical Laboratory Safety through an Academic/Industrial Collaboration,” Huston, E. M.; Milligan, J. A.; Powell, J. R.; Smith, A. M.; Neal, D.; Duval, K. M.; Di Nardo, M. A.; Stoddard, C.; Bell, P. A.; Berning, A. W.; Wipf, P.; Bandik, G. C. J. Chem. Educ. 2018, 95 (4), (4), 577-583
“Spontaneous DNA Damage to the Nuclear Genome Promotes Senescence, Redox Imbalance and Aging,” Robinson, A. R.; Yousefzadeh, M. J.; Rozgaja, T. A.; Wang, J.; Li, X.; Tilstra, J. S.; Feldman, C. H.; Gregg, S. Q.; Johnson, C. H.; Skoda, E. M.; Frantz, M.-C.; Bell-Temin, H.; Pope-Varsalona, H.; Gurkar, A. U.; Nasto, L. A.; Robinson, R. A. S.; Fuhrmann-Stroissnigg, H.; Czerwinska, J.; McGowan, S. J.; Cantu-Medellin, N.; Harris, J. B.; Maniar, S.; Ross, M. A.; Trussoni, C. E.; LaRusso, N. F.; Cifuentes-Pagano, E.; Pagano, P. J.; Tudek, B.; Vo, N. V.; Rigatti, L. H.; Opresko, P. L.; Beer-Stolz, D.; Watkins, S. C.; Burd, C. E.; Croix, C. M. S.; Siuzdak, G.; Yates, N. A.; Robbins, P. D.; Wang, Y.; Wipf, P.; Kelley, E.; Niedernhofer, L. J. Redox Biol. 2018, 17, 259-73
“Combination of a Thioxodihydroquinazolinone with Cisplatin Eliminates Ovarian Cancer Stem Cell-Like Cells (CSC-LCs) and Shows Preclinical Potential,” Ma, J.; Van Houten, B.; Qian, W.; Ma, J.; Salamoun, J.; Wipf, P.; Edwards, R. Oncotarget 2018, 9, (5), 6042-6054
“Structure-Based Virtual Screening Identifies a Small-Molecule Inhibitor of the Profilin 1-Actin Interaction,” Gau, D.; Lewis, T.; McDermott, L.; Wipf, P.; Koes, D.; Roy, P. J. Biol. Chem. 2018, 293, (7), 2606-2616
“The GS-Nitroxide JP4-039 Improves Intestinal Barrier and Stem Cell Recovery in Irradiated Mice,” Wei, L.; Leibowitz, B. J.; Epperly, M.; Bi, C.; Li, A.; Steinman, J.; Wipf, P.; Li, S.; Zhang, L.; Greenberger, J.; Yu, J. Sci. Rep. 2018, 8, (1), 2072
“Evaluation of Mitochondrial Bioenergetics, Dynamics, Endoplasmic Reticulum-Mitochondria Crosstalk, and Reactive Oxygen Species in Fibroblasts from Patients with Complex I Deficiency,” Leipnitz, G.; Mohsen, A.-W.; Karunanidhi, A.; Seminotti, B.; Markantone, D. M.; Grings, M.; Mihalik, S. J.; Vockley, J.; Leipnitz, G.; Grings, M.; Roginskaya, V. Y.; Van Houten, B.; Wipf, P.; Vockley, J. Sci. Rep. 2018, 8, (1), 1165
“Liquid Chromatography-Tandem Mass Spectrometric Assay for the Quantitation of the Novel Radiation Protective Agent and Radiation Mitigator JP4-039 in Murine Plasma,” Christner, S.; Guo, J.; Parise, R. A.; Ringeval, M.; Hoye, A. T.; Wipf, P.; Epperly, M. W.; Greenberger, J. S.; Beumer, J. H.; Eiseman, J. L. J. Pharm. Biomed. Anal. 2018, 150, 169-175
“New Cav2 Calcium Channel Gating Modifiers with Agonist Activity and Therapeutic Potential to Treat Neuromuscular Disease,” Wu, M.; White, H. V.; Boehm, B.; Meriney, C. J.; Kerrigan, K.; Frasso, M.; Liang, M.; Gotway, E. M.; Wilcox, M.; Johnson, J. W.; Wipf, P.; Meriney, S. D. Neuropharmacol. 2018, 131, 176-189
“Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways,”  Steinman, J.; Epperly, M.; Hou, W.; Willis, J.; Wang, H.; Fisher, R.; Liu, B.; Bahar, I.; McCaw, T.; Kagan, V.; Bayir, H.; Yu, J.; Wipf, P.; Li, S.; Huq, M. S.; Greenberger, J. S.; Liu, B.; Bavar, I.; Kagan, V.; Bayir, H.; Yu, J.; Wipf, P.; Li, S. Rad. Res. 2018, 189, 68-83
“Lambert-Eaton Myasthenic Syndrome: Mouse Passive-Transfer Model Illuminates Disease Pathology and Facilitates Testing Therapeutic Leads,” Meriney, S. D.; Tarr, T, B.; Ojala, K. S.; Wu, M.; Li, Y.; Lacomis, D.; Garcia-Ocana, A.; Liang, M.; Valdomir, G. Ann. NY Acad. Sci. 2018, 1412, 73-81
“Small Molecule Targeting of PTPs in Cancer,” Lazo, J. S.; McQueeney, K. E.; Burnett, J. C.; Wipf, P.; Sharlow, E. R. Int. J. Biochem. Cell Biol. 2018, 96, 171-181
“t-BuOOH Induces Ferroptosis in Human and Murine Cell Lines,” Wenz, C.; Faust, D.; Linz, B.; Turmann, C.; Nikolova, T.; Bertin, J.; Gough, P.; Wipf, P.; Schröder, A. S.; Krautwald, S.; Dietrich, C. Arch. Toxicol. 2018, 92, (2), 759-775
“Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(Isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone,” Masoodi, K. Z.; Eisermann, K.; Yang, Z.; Dar, J. A.; Pascal, L. E.; Nguyen, M.; O'Malley, K.; Parrinello, E.; Feturi, F. G.; Kenefake, A. N.; Nelson, J. B.; Johnston, P. A.; Wipf, P.; Wang, Z. Endocrinol. 2017, 158, (10), 3152-3161
“N-Acetyl-L-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione,” Gleixner, A. M.; Hutchison, D. F.; Sannino, S.; Bhatia, T. N.; Leak, L. C.; Flaherty, P. T.; Wipf, P.; Brodsky, J. L.; Leak, R. K. Mol. Pharmacol. 2017, 92, (5), 564-575
“Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-Based Small Molecules,” Masoodi, K. Z.; Xu, Y.; Dar, J. A.; Eisermann, K.; Pascal, L. E.; Parrinello, E.; Ai, J.; Johnston, P. A.; Nelson, J. B.; Wipf, P.; Wang, Z. Mol. Cancer Ther. 2017, 16, (10), 2120-2129
“Indole Synthesis by Palladium-Catalyzed Tandem Allylic Isomerization - Furan Diels-Alder Reaction,” Xu, J.; Wipf, P. Org. Biomol. Chem. 2017, 15, (34), 7093-7096
“Eight-Step Enantioselective Total Synthesis of (−)-Cycloclavine,” McCabe, S. R.; Wipf, P. Angew. Chem. Int. Ed. 2017, 56, (1), 324-327
“Mechanism of Action of Selective Inhibitors of IL-6 Induced STAT3 Pathway in Head and Neck Cancer Cell Lines,” Sen, M.; Pollock, N. I.; DeGrave, K.; Joyce, S. C.; Freilino, M. L.; Johnston, P. A.; Hua, Y.; Camarco, D. P.; Close, D. A.; Huryn, D. M.; Wipf, P.; Grandis, J. R. J. Chem. Biol. 2017, 10, 129-141
“Induction of TGF-b by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350,”  Epperly, M. W.; Rhieu, B.-H.; Franicola, D.; Dixon, T.; Cao, S.; Zhang, X.; Shields, D.; Wang, H.; Wipf, P.; Greenberger, J. S. In Vivo 2017, 31, 159-168
“Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells,” Tyurina, Y. Y.; Lou, W.; Qu, F.; Tyurin, V. A.; Mohammadyani, D.; Liu, J.; Huttemann, M.; Frasso, M. A.; Wipf, P.; Bayir, H.; Greenberger, M. L.; Kagan, V. E. ACS Chem. Biol. 2017, 12, 265-281
“A Structure-activity Relationship Study of ABCC2 Inhibitors,” Wissel, G.; Deng, F.; Kudryavtsev, P.; Ghemtio, L.; Wipf, P.; Xhaard, H.; Kidron, H. Eur. J. Pharm. Sci. 2017, 103, 60-69
“Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators,” Epperly, M. W.; Sacher, J. R.; Krainz, T.; Zhang, X.; Wipf, P.; Liang, M.; Fisher, R.; Li, S.; Wang, H.; Greenberger, J. S. In Vivo 2017, 31, 39-43
“ACS Medicinal Chemistry Letters: Technology Notes,” Wipf, P. ACS Med. Chem. Lett. 2017, 8, (1), 1-2
“A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage,” Brand, R. M.; Epperly, M. W.; Stottlemyer, J. M.; Skoda, E. M.; Gao, X.; Li, S.; Huq, S.; Wipf, P.; Kagan, V. E.; Greenberger, J. S.; Falo, L. D. J. Invest. Derm. 2017, 137, 576-586
“Elucidating Mitochondrial ETC Supercomplexes in the Heart During Ischemia-Reperfusion,” Jang, S.; Lewis, T. S.; Powers, C.; Khuchua, Z.; Baines, C. P.; Wipf, P.; Javadov, S. Antioxid. Redox Signal. 2017, 27, (1), 57-69
“A Threonine Turnstile Defines a Dynamic Amphiphilic Binding Motif in the AAA ATPase p97 Allosteric Binding Site,” Burnett, J.; Lim, C.; Peyser, B. D.; Samankumara, L. P.; Kovaliov, M.; Colombo, R.; Bulfer, S.; LaPorte, M.; Hermone, A.; McGrath, C.; Arkin, M.; Gussio, R.; Huryn, D.; Wipf, P. Org. Biomol. Chem. 2017, 15, 4096-4114
“Optimization of Pyrazole-Containing 1,2,4-Triazolo-[3,4-B]Thiadiazines, a New Class of STAT3 Pathway Inhibitors,” Laporte, M. G.; Wang, Z.; Colombo, R.; Garzan, A.; Peshkov, V. A.; Liang, M.; Johnston, P. A.; Schurdak, M. E.; Sen, M.; Camarco, D. P.; Hua, Y.; Pollock, N. I.; Lazo, J. S.; Grandis, J. R.; Wipf, P.; Huryn, D. M. Bioorg. Med. Chem. Lett. 2016, 26, 3581-3585
“Total Synthesis and Biological Evaluation of Tubulysin Analogues,” Colombo, R.; Wang, Z.; Han, J.; Balachandran, R.; Daghestani, H. N.; Camarco, D. P.; Vogt, A.; Day, B. W.; Mendel, D.; Wipf, P. J. Org. Chem. 2016, 81, (21), 10302-10320
“Dihydropyrimidinones and -Thiones With Improved Activity Against Human Polyomavirus Family Members,” Manos-Turvey, A.; Al-Ashtal, H. A.; Needham, P. G.; Hartline, C. B.; Prichard, M. N.; Wipf, P.; Brodsky, J. L. Bioorg. Med. Chem. Lett. 2016, 26, 5087-5091
“A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis,” Krainz, T.; Gaschler, M. M.; Lim, C.; Sacher, J. R.; Stockwell, B. R.; Wipf, P. ACS Cent. Sci. 2016, 2, (9), 653-659
“Hydrophosphination of Bicyclo[1.1.0]butane-1-carbonitriles,” Milligan, J. A.; Busacca, C. A.; Senanayake, C. H.; Wipf, P. Org. Lett. 2016, 18, (17), 4300-4303
“Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer ,” Johnson, J. K.; Skoda, E. M.; Zhou, J.; Parrinello, E.; Wang, D.; O'Malley, K.; Eyer, B. R.; Kazancioglu, M. Z.; Eisermann, K.; Johnston, P. A.; Nelson, J. B.; Wang, Z.; Wipf, P. ACS Med. Chem. Lett. 2016, 7, (8), 785-790
“Allosteric Modulation of Phosphatase Activity May Redefine Therapeutic Value,” Salamoun, J. M.; Wipf, P. J. Med. Chem. 2016, 59, (17), 7771-7772
“Combined Chemical-Genetic Approach Identifies Cytosolic HSP70 Dependence in Rhabdomyosarcoma,” Sabnis, A. J.; Guerriero, C. J.; Olivas, V.; Sayana, A.; Shue, J.; Flanagan, J.; Asthana, S.; Paton, A. W.; Paton, J. C.; Gestwicki, J. E.; Walter, P.; Weissman, J. S.; Wipf, P.; Brodsky, J. L.; Bivona, T. G. Proc. Natl. Acad. Sci. USA 2016, 113, (32), 9015-9020
“Photooxygenation of an Amino-Thienopyridone Yields a More Potent PTP4A3 Inhibitor,” Salamoun, J. M.; McQueeney, K. E.; Patil, K.; Geib, S. J.; Sharlow, E. R.; Lazo, J. S.; Wipf, P. Org. Biomol. Chem. 2016, 14, 6398-6402
“Synthesis and Evaluation of Potent KCNQ2/3-specific Channel Activators,” Kumar, M.; Reed, N.; Liu, R.; Aizenmann, E.; Wipf, P.; Tzounopoulos, T. Mol. Pharmacol. 2016, 89, (6), 667-677
“Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice,” Shinde, A.; Berhane, H.; Rhieu, B. H.; Kalash, R.; Xu, K.; Goff, J.; Epperly, M. W.; Franicola, D.; Zhang, X.; Dixon, T.; Shields, D.; Wang, H.; Greenberger, J. S.; Wipf, P.; Parmar, K.; Guinan, E.; Kagan, V.; Tyurin, V.; Ferris, R. L.; Zhang, X.; Li, S. Radiat. Res. 2016, 185, 134-150
“Total Synthesis, Biosynthesis and Biological Profiles of Clavine Alkaloids,” McCabe, S. R.; Wipf, P. Org. Biomol. Chem. 2016, 14, 5894-5913
“Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells,” Johnston, P. A.; Nguyen, M. M.; Dar, J. A.; Ai, J.; Wang, Y.; Masoodi, K. Z.; Shun, T.; Shinde, S.; Camarco, D. P.; Hua, Y.; Huryn, D. M.; Wilson, G. M.; Lazo, J. S.; Nelson, J. B.; Wipf, P.; Wang, Z. Assay Drug Dev. Technol. 2016, 14, 226-239
“Mitochondrial Targeting of XJB-5-131 Attenuates or Improves Pathophysiology in HdhQ150 Animals with Well-Developed Disease Phenotypes,” Polyzos, A.; Holt, A.; Brown, C.; Cosme, C.; Wipf, P.; Gomez-Marin, A.; Castro, M. R.; Ayala-Peña, S.; McMurray, C. T. Hum. Mol. Gen. 2016, 25, (9), 1792-1802
“Click Chemistry: Straining to React,” Milligan, J. A.; Wipf, P. Nat. Chem. 2016, 8, 296-297
“Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 Map Kinase Inhibitor,” Wilson, B. a. P.; Guszczynski, T.; Mitchell, C. A.; Alam, M. S.; Ashwell, J. D.; Jakob, M.; Shenoy, S. R.; Goncharova, E. I.; Evans, J. R.; Wipf, P.; Liu, G.; O'Keefe, B. R. J. Biomol. Screen. 2016, 21, 277-289
“2.3 Å Resolution Cryo-EM Structure of Human p97 and Mechanism of Allosteric Inhibition,” Banerjee, S.; Bartesaghi, A.; Merk, A.; Rao, P.; Bulfer, S. L.; Yan, Y.; Green, N.; Mroczkowski, B.; Neitz, R. J.; Wipf, P.; Falconieri, V.; Deshaies, R. J.; Milne, J. L. S.; Huryn, D.; Arkin, M.; Subramaniam, S. Science 2016, 351, (6275), 871-875.
“Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway,”  Alverez, C.; Bulfer, S. L.; Chakrasali, R.; Chimenti, M. S.; Deshaies, R. J.; Green, N.; Kelly, M.; Laporte, M. G.; Lewis, T. S.; Liang, M.; Moore, W. J.; Neitz, R. J.; Peshkov, V. A.; Walters, M. A.; Zhang, F.; Arkin, M. R.; Wipf, P.; Huryn, D. M. ACS Med. Chem. Lett. 2016, 7, 182-187
“The Cytotoxic Effects of Regorafenib in Combination with Protein Kinase D Inhibition in Human Colorectal Cancer Cells,” Wei, N.; Chu, E.; Wu, S.-Y.; Wipf, P.; Schmitz J. C. Oncotarget 2015, 6, 4745-4756
“HCS Campaign to Identify Selective Inhibitors of IL-6-Induced Stat3 Pathway Activation in Head and Neck Cancer Cell Lines,” Johnston, P. A.; Sen, M.; Hua, Y.; Camarco, D. P.; Shun, T. Y.; Lazo, J. S.; Wilson, G. M.; Resnick, L. O.; La Porte, M. G.; Wipf, P.; Huryn, D. M.; Grandis, J. R. Assay Drug Dev. Technol. 2015, 13, 356-376
“Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome,” Tarr, T.; Wipf, P.; Meriney, S. Mol. Neurobiol. 2015, 52, (1), 456-463
“Gene Therapy for Mucositis,” Greenberger, J. S.; Epperly, M. W.; Wipf, P.; Li, S.; Kagan, V.; Gao, X. In Genomics Personalized Medicine and Oral Disease; Sonis S. T. Ed.; Springer International Publishing Switzerland 2015, 345-362
“Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97,” Alverez, C.; Arkin, M. R.; Bulfer, S. L.; Colombo, R.; Kovaliov, M.; Laporte, M. G.; Lim, C.; Liang, M.; Moore, W. J.; Neitz, R. J.; Yan, Y.; Yue, Z.; Huryn, D. M.; Wipf, P. ACS Med. Chem. Lett. 2015, 6, 1225-1230
“Bis-Cyclopropane Analog of Disorazole C1 is a Microtubule-Destabilizing Agent Active in ABCB1-Overexpressing Human Colon Cancer Cells,” Wu, S.; Guo, Z.; Hopkins, C. D.; Wei, N.; Chu, E.; Wipf, P.; Schmitz, J. C. Oncotarget 2015, 6, 40866-40879
“Mitochondria-Targeted Antioxidant Preserves Contractile Properties and Mitochondrial Function of Skeletal Muscle in Aged Rats,” Javadov, S.; Jang, S.; Rodriguez-Reyes, N.; Rodriguez-Zayas A. E.; Soto Hernandez, J.; Frontera, W.; Krainz, T.; Wipf, P.; Frontera, W. Oncotarget 2015, 6, 39469-39481
“Cascade Cyclization Triggered by Imine Formation. Formal Synthesis of the Alkaloid (±)-Stemoamide and its 9a-Epimer,” Brito, G. A.; Sarotti, A. M.; Wipf, P.; Pilli, R. A. Tetrahedron Lett. 2015, 56, 6664-6668
“Mitochondrial Targeted β-Lapachone Induces Mitochondrial Dysfunction and Catastrophic Vacuolization in Cancer Cells,” Ma, J.; Lim, C.; Sacher, J. R.; Van Houten, B.; Qian, W.; Wipf, P. Bioorg. Med. Chem. Lett. 2015, 25, 4828-4833
“Exploring the Structure-Activity Relationships of ABCC2 Modulators using a Screening Approach,” Wissel, G.; Kudryavtsev, P.; Ghemtio, L.; Tammela, P.; Yliperttula, M.; Wipf, P.; Finel, M.; Urtti, A.; Kidron, H.; Xhaard, H. Bioorg. Med. Chem. 2015, 23, 3513-3525
“One-pot Hydrozirconation/Copper‐catalyzed Conjugate Addition of Alkylzirconocenes to Enones,” Arnold, D.; Krainz, T.; Wipf, P. Org. Synth. 2015, 92, 277-295
“The Effect of Structure and Mechanism of the Hsp70 Chaperone on the Ability to Identify Chemical Modulators and Therapeutics,” Manos-Turvey, A.; Brodsky, J.; Wipf, P. Top. Med. Chem. 2015, 16, 1-49
“Conformational Restriction and Steric Hindrance in Medicinal Chemistry,” Wipf, P.; Skoda, E. M.; Mann, A. In The Practice of Medicinal Chemistry 4th ed.; Wermuth C. G. Aldous D. Raboisson P. Rognan D. Ed.; Academic Press: Burlington MA Chapter 11 2015, 279-301
“Heat Shock Protein Responses to Aging and Proteotoxicity in the Olfactory Bulb,” Crum, T. S.; Gleixner, A. M.; Posimo, J. M.; Mason, D. M.; Broeren, M. T.; Heinemann, S. D.; Wipf, P.; Brodsky, J. L.; Leak, R. K. J. Neurochem. 2015, 133, 780-794
“Heat Shock Protein Defenses in the Neocortex and Allocortex of the Telencephalon,”  Posimo, J. M.; Weilnau, J. N.; Gleixner, A. M.; Broeren, M. T.; Weiland, N. L.; Brodsky, J. L.; Wipf, P.; Leak, R. K. Neurobiol. Aging 2015, 36, 1924-1937
“The Combination of Thioxodihydroquinazolinones and Platinum Drugs Reverses Platinum Resistance in Tumor Cells by Inducing Mitochondrial Apoptosis Independent of Bax and Bak,” Qian, W.; Salamoun, J.; Wang, J.; Roginskaya, V.; Van Houten, B.; Wipf, P. Bioorg. Med. Chem. Lett. 2015, 25, 856-863
“Ring-Strain-Enabled Reaction Discovery: New Heterocycles from Bicyclo[1.1.0]butanes,” Walczak, M. A. A.; Krainz, T.; Wipf, P. Acc. Chem. Res. 2015, 48, 1149-1158
“Synthesis and Biological Evaluation of 3-Aminoisoquinoline-1(2H)-one Based Inhibitors of the Dual-Specificity Phosphatase Cdc25B,” Rosenker, K. M. G.; Paquette, W. D.; Johnston, P. A.; Sharlow, E. R.; Vogt, A.; Bakan, A.; Lazo, J. S.; Wipf, P. Biorg. Med. Chem. Lett. 2015, 23, 2810-2818
“SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth in Vivo by Inducing G2/M Cell Cycle Arrest,” Tandon, M.; Carder E. J.; Xu, S.; Wang, Q. J.; Salamoun J., M.; Farber, E.; Wipf, P.; Deng, F.; Tang, H. PLoS One 2015, 10, e0119346
“Antioxidant Approaches to Management of Ionizing Irradiation Injury,” Greenberger, J.; Kagan, V.; Bayir, H.; Wipf, P.; Epperly, M. Antioxidants 2015, 4, (1), 82-101
“ Synthesis of Anti-inflammatory α-and β-Linked Acetamidopyranosides as Inhibitors of Toll-like Receptor 4 (TLR4),” Wipf, P.; Eyer, B. R.; Yamaguchi, Y.; Zhang, F.; Neal, M. D.; Sodhi, C. P.; Good, M.; Branca, M.; Prindle Jr, T.; Lu, P.; Brodsky, J. L.; Hackam, D. J. Tetrahedron Lett. 2015, 56, 3097-3100
“Deciphering of Mitochondrial Cardiolipin Oxidative Signaling in Cerebral Ischemia-Reperfusion,” Ji, J.; Baart, S.; Vikulina, A. S.; Clark, R. S. B.; Anthonymuthu, T. S.; Tyurin, V. A.; Du, L.; St Croix, C. M.; Tyurina, Y. Y.; Lewis, J.; Skoda, E. M.; Kline, A. E.; Kochanek, P. M.; Wipf, P.; Kagan, V. E.; Bayir, H. J. Cereb. Blood Flow Metab. 2015, 35, 319-328